EMP2 re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma
نویسندگان
چکیده
منابع مشابه
MiR‐24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1
Radioresistance remains a major problem in the treatment of patients suffering from nasopharyngeal carcinoma (NPC). A better understanding of the mechanisms of radioresistance may generate new strategies to improve NPC patients' responses to therapy. This study was designed to investigate the effect of microRNA on the radiosensitivity of NPC cells. A microRNA microarray indicated that miR-24 wa...
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Radiotherapy has long been considered as the mainstay of treatment for nasopharyngeal carcinoma (NPC). However, locoregional recurrence or distant metastasis may occur in some patients due to the radiation resistance of cancer cells. Autophagy plays a vital role in protecting cells against radiation. However, the mechanism of autophagy in radiation therapy remains obscure. In the present study,...
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BACKGROUND Previous work has proposed that celecoxib may be able to enhance the effects of radiotherapy. However, the underlying mechanism of this activity has not yet been determined. METHODS The cell colony formation assay after the combination of celecoxib and radiation treatment was done on C666-1, CNE-1 and CNE-2 nasopharyngeal carcinoma cells, which expressed different COX-2 levels. Mor...
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BACKGROUND FGF receptor (FGFR) family can be activated by FGFs and play important roles in regulating cell growth, differentiation, migration and angiogenesis. Recent studies suggested that FGFR4 could regulate several processes including tumor progression. Nasopharyngeal carcinoma (NPC) is a malignancy with a high occurrence in Southeast Asia and Southern China. However, the molecule mechanism...
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Squamous cell carcinoma antigen 1 (SCCA1) is implicated in the growth, differentiation and metastasis of squamous cell carcinoma. Previously we found that SCCA1 protein level was lower in nasopharyngeal carcinoma (NPC) than in nasopharyngeal epithelial tissue. This study aimed to investigate the mechanism by which SCCA1 expression is downregulated in NPC. Four NPC cell lines including CNE1, CNE...
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ژورنال
عنوان ژورنال: Tumor Biology
سال: 2017
ISSN: 1010-4283,1423-0380
DOI: 10.1177/1010428317695972